Eight different drugs or drug candidates with anti-viral, anti-inflammatory and other properties have been formulated as Novochizol aerosols for intra-pulmonary delivery, and tested on mice using an in-house multiplex inhalator:
The following compounds have been formulated:
Angiotensin Type 1 Receptor inhibitors (ARBs ) : Lostartan, Valsartan, Temisartan. More info
ARBs inhibit the internalization and inactivation of ACE2, the main receptor of SARS-CoV-2, which also converts pro-inflammatory, vasoconstrictive Angiotensin-2 into anti-inflammtory, vasodilating Angiotensin-1, 7. ARBs thus act both as anti-virals and anti-inflsammatory drugs. They have been shown to protect COVID-19 patients from severe lung pathologies.
Digoxin, an inhibitor of Mpro, the main protease of SARS-COV-2 and related viruses. More info
Soloxolone methyl, a pleiotropic anti-viral, anti-inflammatory and anti-tumor agent.
Markov, A.V., Sen’kova, A.V., Warszycki, D. et al. Soloxolone methyl inhibits influenza virus replication and reduces virus-induced lung inflammation. Sci Rep 7, 13968 (2017). https://doi.org/10.1038/s41598-017-14029-0
Markov AV, Sen’kova AV, Zenkova MA, Logashenko EB. [Novel Glycyrrhetinic Acid Derivative Soloxolone Methyl Inhibits the Inflammatory Response and Tumor Growth in vivo]. Molekuliarnaia Biologiia. 2018 Mar-Apr;52(2):306-313. https://doi.org/10.7868/s0026898418020143.
LIS-M, an inhibitor if inducible NO-synthase, displaying strong anti-inflammatory, analgesic and antipyretic properties.
Undisclosed inactivator of thrombocytosis
PAV-0056, a bradykinin receptor antagonist.