Novochizol makes it possible to generate aqueous suspensions with hydrophobic active ingredients that have all the properties of bona fide solutions.
There are two simple methods to achieve this:
A. Impregnating Novochizol nanoparticles
In this approach the active ingredient is suspended in any water-miscible solvent (DMSO, THF, ethanol, etc.) and simply added to an aqueous suspension of Novochizol. As the solvent is diluted or evaporated, the active ingredient enters the Novochizol nanoparticles that essentially act as a sponge. The process is diagramed below:
In this approach the active ingredient is dissolved at high concentrations in the appropriate solvent (for example hot N-methyl pyrrolidone) and injected with a syringe into to a low concentration aqueous suspension of Novochizol. The active ingredient aggregates (crystalizes) and the aggregates (that can measure 100 nm or more) are covered with Novochizol, which acts as an emulsifier. The process is diagramed below:
The two methods yield extremely differentiated pharmacokinetic profiles . Intermediate scenarios, combining the two methods, allow to fine-tune pharmacokinetic profiles to precisely match the needed therapeutic rationale.