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BIOAVANTA-BOSTI* ANNOUNCES IMMEDIATE AVAILABILITY OF ITS CHITOSAN NANOPARTICLE TECHNOLOGY TO FORMULATE AEROSOL DRUGS TO TREAT COVID-19

NovochizolTM nanoparticle aerosol formulation can be used to deliver and confine any potential anti- COVID-19 drug to the lungs of acutely ill patients.

Rolle, Switzerland and Novosibirsk, Russia, March 26th 2020: Bioavanta-Bosti*, a leader in chitosan nanoparticles research, today announced the release of Novochizol TM a unique polysaccharide nanotechnology which can be used to encapsulate any active pharmaceutical ingredient – small molecule or biologic – for localized delivery and sustained release in any tissue or organ.

Bioavanta-Bosti has just completed the development of a 48-hour Novochizol TM-based manufacturing process to generate intra-pulmonary drug delivery formulations suitable for treating COVID-19 patients.

The process is illustrated in the following video: https://youtu.be/9Im6z1BsesU

“We may not know much about SARS-CoV-2 disease mechanisms, but we do know that the lungs are the place where the infection and the resulting inflammatory response cause tissue damage with dire consequences” explains Vanya Loroch, Novochizol representative in Switzerland. “Accordingly, the lungs are the place where an effective localized pharmacological treatment may become a life saver”.

Vladislav Fomenko, the inventor of Novochizol TM technology explains that the chitosan nanoparticles are fully biocompatible, strongly adhere to lung epithelial tissues and ensure sustained release, without systemic distribution. Extensive preclinical testing , conducted by Bioavanta-Bosti’s academic partners**, indicates that Novochizol TM  is a safe and effective drug delivery technology.

“We are interested in partnering with drug developers and clinical researchers to rapidly develop a repurposed drug or new molecular or biological entity formulations to help treat severe COVID-19 infection, in the lungs. Based on our proof of concept testing with Losartan, Valsartan, Telmisartan and Digoxin, we know Novochizol TM aerosols can deliver a therapeutic dose to a patient over a period ranging from 25 minutes to 3 hours.”

On Friday the 13th of March, the EMA has announced that the Agency will provide full fee waivers for scientific advice applications from developers of potential therapeutics (to treat the disease) or vaccines (to prevent the disease) against the novel coronavirus disease (COVID-19).

Any entity interested in partnering to fast-track an effective therapeutic solution against COVID-19 is invited to contact Bioavanta-Bosti as soon as possible.

More information: www.novochizol.ch e-mail: partnering@novochizol.ch

CORPORATE HEADQUARTERS:

Kyriacos Scordis
BOSTI TRADING LTD
The Business Forum
30 Karpenisi Street
1077 Nicosia

CYPRUS
office@bosti.com.cy

MEDIA CONTACT:

Vanya Loroch, PhD
LOROCH CTLS
Chemin des Vidies 2
1186 Essertines-sur-Rolle

SWITZERLAND
Tel. +41 76 370 73 25
vanya@loroch.ch

Novochizol TM  is a proprietary nanotechnology  of Bosti Trading LTD (http://bosti.com.cy)  pursuant to the creation of a joint-venture  with Bioavanta LLC (http://www.bioavanta.com)