Drug Formulation

DRUG FORMULATION

Targeted delivery and sustained release of any API using any formulation modality

Why Novochizol^TM ?

Small molecules, peptides, nucleic acids, proteins, viruses, cells can all be formulated
Effective formulation of hydrophobic, recalcitrant APIs
Localized drug delivery at site of administration with no systemic diffusion
Strong bioadhesion and tissue penetration
Customizable sustained release
Multiple modalties: injectables, aerosols, oral, topical and solid matrices
Protection against physical, chemical and enzymatic degradation
Intracellular transpost of all active ingredients, including proteins
Biocompatibility and safety inherited from chitosan (GRAS)
Inherent anti-inflammatory properties

Research and Development

Targeted, intracellular drug delivery

Novochizol^TM technology can deliver all classes of APIs - small molecules, peptides, nucleic acids and large proteins - inside different cells, only at the site of administration. It opens a world of possibilities for all active ingredients to reach new targets.

Hyperhidrosis (Botulinum toxin)

Injectable Novochizol^TM formulations of botulinum toxin prolong inhibition of excessive transpiration by at least 200%. They also offer the promise of injection-free, topical administration

Atrial Fibrillation (Botulinum toxin)

Novochizol^TM - formulated botulinum toxin injections into epicardial fat pads lead to long-term suppression of atrial fibrillation and complete abolition of cardiac vagal response.

Formulation of poorly soluble APIs for multiple indications

Novochizol^TM technology can help formulate APIs when all other approaches have failed. A collaboration with Boehringer-Ingelheim is under way to formulate five drug candidates with diverse properties and a range of mechanistic targets.

Resistant Hypertension (Botulinum toxin)

Novochizol^TM - formulated botulinum toxin injections into renal arteries inhibit renin release, resulting in lower arterial blood pressure over extended periods of time. Novochizol^TM enables a new mechanism of action.

Oncology: Targeted therapies and immuno-therapies

Thanks to tissue-adherence of Novochizol^TM -formulated APIs at the site of administration, our technology offers an unprecedented potential to deliver virtually any anti-cancer drug only where it is needed.