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Novochizol™ technology can deliver all classes of APIs – small molecules, peptides, nucleic acids, proteins – inside different cells in a targeted manner, simply by delivering the formulation to the tissue of interest by injection, spraying or topical application.
BoNT/A delivered by Novochizol™ to renal arteries enters renal cells where it inhibits renin release, leading to lower blood pressure, most likely via a general mechanism that inhibits vesicular secretion, opening countless possibilities.
Moreover, the delivery is localized, without systemic distribution and biological effects are sustained over long periods of time.
BoNT/A, histochemically visualized with an anti BoNT 4.1 antibody, confined to an arteriole in the renal capsule
Cornea: Fluorescein-labeled original chitosan or Novochizol™ suspensions were applied to the eyes of experimental animals (CBA mice). After 6 hours, the animals were euthanized, and the cornea examined by fluorescence microscopy:
Small intestines: Fluorescein-labeled Novochizol™ suspensions were administered per os to mice. After 8 hours, cross-sections of small intestines were stained with Hoechst 33258 and examined by fluorescence microscopy.
Fluorescence microscopy of a single leucocyte exposed to a suspension of Fluorescein-labeled Novochizol™ and died with Hoechst 33258 DNA -specific stain:
